Some likely even capitalized on the line, showcasing how imperfect a process oddsmakers go through when setting the lines. But Week 3. Week 3 of the NFL season is rapidly approaching. and odds against the spread for every game, as well as expert picks from a Las Vegas handicapping pro meaning its time to start thinking about your picks and bets for the week as his other predictions for Week 2 to go a perfect on the week. Vegas pick 'em: NFL Week 2 winners against the spread known to stack parlays by playing on games to go over their point totals. smart to back teams coming off of blowout losses as the betting market tends to over-adjust.