College football Week 2 picks against spread: Oklahoma, Ohio State a tough pick 'em. ncaa -football September 9, am EDT September 9, am. And one of the biggest college football odds movements this week involves Louisville. Pro bettors hammered the Cardinals, moving the spread. Week 2 college football picks against the spread: Don't trust USC Joshua S. Kelly-USA TODAY Sports Boise State's defense is good, but a good performance against The Cardinals will win by at least two scores. College football Week 2 picks against spread: Oklahoma, Ohio State a tough pick 'em. ncaa -football September 9, am EDT September 9, am. Bruce Feldman's Week 13 college football picks against the spread. The good: picking Houston to give Lamar Jackson and Louisville all sorts of problems. The bad: Rick Osentoski USA TODAY Sports . 2 Preview: Twins at Yankees 3 Cardinals ' Weaver takes mound with majors' longest active win. College football picks, Week 4: Oklahoma State, TCU ready for a shootout Here's what we've got for Week 4 (point spreads provided courtesy of olenchinkov.info as of Sept. A&M's defense isn't good, but the Aggies — who, by the way, are likely Expect lots of points in this one, and a Cardinal win.